At least 30 orthobunyaviruses have been associated with human disease ; the oropouche virus , also a member of the simbu serogroup , causes a febrile disease often associated with headaches , dizziness , skin rash , and malaise , whereas the iquitos virus can cause diarrhea , vomiting , and nausea .

至少有30种正布尼亚病毒与人类疾病有关系；奥罗波克病毒，也是西姆堡血清群的一个成员，引起常与发热性疾病相关的头痛、头晕、皮疹和不适等症状，而伊基托斯病毒可引起腹泻、呕吐和恶心。